Gene information
Official symbol LPL
Official full name lipoprotein lipase
Gene type protein-coding gene
Chromosome8p21.3
Previous symbolLIPD
Gene familyLipases
Resources
Entrez Gene 4023
HGNC HGNC:6677
Ensembl ENSG00000175445
Vega OTTHUMG00000036645
UCSC uc003wzk.5
GO terms: 111 records
GO Description Category LogP Number of genes Detail
GO:0001819 positive regulation of cytokine production GO Biological Processes -44.1872667 64 More
GO:0004465 lipoprotein lipase activity GO Molecular Functions -3.72958795 3 More
GO:0004620 phospholipase activity GO Molecular Functions -8.28406161 12 More
GO:0004806 triglyceride lipase activity GO Molecular Functions -2.50427121 3 More
GO:0005509 calcium ion binding GO Molecular Functions -14.7764642 80 More
GO:0005539 glycosaminoglycan binding GO Molecular Functions -36.7680176 44 More
GO:0006631 fatty acid metabolic process GO Biological Processes -20.3287405 33 More
GO:0006633 fatty acid biosynthetic process GO Biological Processes -12.0711739 16 More
GO:0006638 neutral lipid metabolic process GO Biological Processes -9.91206723 13 More
GO:0006639 acylglycerol metabolic process GO Biological Processes -9.97063695 13 More
GO:0006641 triglyceride metabolic process GO Biological Processes -9.32996784 11 More
GO:0006644 phospholipid metabolic process GO Biological Processes -2.96272379 13 More
GO:0007584 response to nutrient GO Biological Processes -29.4823239 48 More
GO:0008201 heparin binding GO Molecular Functions -33.5542939 37 More
GO:0008289 lipid binding GO Molecular Functions -15.8223476 88 More
GO:0008610 lipid biosynthetic process GO Biological Processes -6.38047816 23 More
GO:0008970 phospholipase A1 activity GO Molecular Functions -3.00303064 3 More
GO:0009266 response to temperature stimulus GO Biological Processes -12.1149168 32 More
GO:0009409 response to cold GO Biological Processes -5.06845562 11 More
GO:0009410 response to xenobiotic stimulus GO Biological Processes -32.6021211 82 More
GO:0009617 response to bacterium GO Biological Processes -52.1760880 83 More
GO:0009743 response to carbohydrate GO Biological Processes -20.6536066 44 More
GO:0009746 response to hexose GO Biological Processes -16.2230361 35 More
GO:0009749 response to glucose GO Biological Processes -15.7538948 34 More
GO:0009991 response to extracellular stimulus GO Biological Processes -42.2178323 102 More
GO:0010743 regulation of macrophage derived foam cell differentiation GO Biological Processes -20.3455172 15 More
GO:0010744 positive regulation of macrophage derived foam cell differentiation GO Biological Processes -12.0744578 9 More
GO:0010883 regulation of lipid storage GO Biological Processes -22.5241589 19 More
GO:0010884 positive regulation of lipid storage GO Biological Processes -7.64826410 7 More
GO:0010885 regulation of cholesterol storage GO Biological Processes -14.3909835 10 More
GO:0010886 positive regulation of cholesterol storage GO Biological Processes -7.90707903 5 More
GO:0016042 lipid catabolic process GO Biological Processes -9.62855375 20 More
GO:0016053 organic acid biosynthetic process GO Biological Processes -15.6178787 26 More
GO:0016298 lipase activity GO Molecular Functions -10.3255371 15 More
GO:0016788 hydrolase activity, acting on ester bonds GO Molecular Functions -4.57583420 56 More
GO:0019433 triglyceride catabolic process GO Biological Processes -7.04725442 6 More
GO:0031347 regulation of defense response GO Biological Processes -64.5971043 148 More
GO:0031349 positive regulation of defense response GO Biological Processes -32.1301903 71 More
GO:0031667 response to nutrient levels GO Biological Processes -41.8130555 98 More
GO:0031668 cellular response to extracellular stimulus GO Biological Processes -10.2327580 36 More
GO:0031669 cellular response to nutrient levels GO Biological Processes -9.42886914 32 More
GO:0031670 cellular response to nutrient GO Biological Processes -9.31154255 13 More
GO:0032103 positive regulation of response to external stimulus GO Biological Processes -58.7273809 118 More
GO:0032642 regulation of chemokine production GO Biological Processes -25.2850711 37 More
GO:0032651 regulation of interleukin-1 beta production GO Biological Processes -19.7300517 34 More
GO:0032652 regulation of interleukin-1 production GO Biological Processes -24.2088254 41 More
GO:0032675 regulation of interleukin-6 production GO Biological Processes -28.2553997 51 More
GO:0032680 regulation of tumor necrosis factor production GO Biological Processes -32.0729913 56 More
GO:0032722 positive regulation of chemokine production GO Biological Processes -22.4503100 21 More
GO:0032731 positive regulation of interleukin-1 beta production GO Biological Processes -11.8061175 13 More
GO:0032732 positive regulation of interleukin-1 production GO Biological Processes -14.7376831 16 More
GO:0032755 positive regulation of interleukin-6 production GO Biological Processes -18.6559032 31 More
GO:0032760 positive regulation of tumor necrosis factor production GO Biological Processes -21.1788990 23 More
GO:0032787 monocarboxylic acid metabolic process GO Biological Processes -19.1871601 38 More
GO:0032994 protein-lipid complex GO Cellular Components -17.0133835 14 More
GO:0034185 apolipoprotein binding GO Molecular Functions -9.05405363 7 More
GO:0034284 response to monosaccharide GO Biological Processes -18.9205843 39 More
GO:0034358 plasma lipoprotein particle GO Cellular Components -17.5986271 14 More
GO:0034361 very-low-density lipoprotein particle GO Cellular Components -8.67626191 7 More
GO:0034367 protein-containing complex remodeling GO Biological Processes -22.5554593 16 More
GO:0034368 protein-lipid complex remodeling GO Biological Processes -23.1924108 16 More
GO:0034369 plasma lipoprotein particle remodeling GO Biological Processes -23.1924108 16 More
GO:0034370 triglyceride-rich lipoprotein particle remodeling GO Biological Processes -9.26986898 6 More
GO:0034372 very-low-density lipoprotein particle remodeling GO Biological Processes -9.66344956 6 More
GO:0034385 triglyceride-rich plasma lipoprotein particle GO Cellular Components -8.67626191 7 More
GO:0042627 chylomicron GO Cellular Components -8.37064445 6 More
GO:0042632 cholesterol homeostasis GO Biological Processes -21.5492593 34 More
GO:0042803 protein homodimerization activity GO Molecular Functions -14.2815375 77 More
GO:0043394 proteoglycan binding GO Molecular Functions -12.1259478 11 More
GO:0043395 heparan sulfate proteoglycan binding GO Molecular Functions -6.54424039 8 More
GO:0044242 cellular lipid catabolic process GO Biological Processes -5.52561510 12 More
GO:0044283 small molecule biosynthetic process GO Biological Processes -16.6163676 33 More
GO:0045598 regulation of fat cell differentiation GO Biological Processes -17.6607153 22 More
GO:0045600 positive regulation of fat cell differentiation GO Biological Processes -4.83398124 7 More
GO:0046394 carboxylic acid biosynthetic process GO Biological Processes -15.6974044 26 More
GO:0046461 neutral lipid catabolic process GO Biological Processes -7.3012399 7 More
GO:0046464 acylglycerol catabolic process GO Biological Processes -7.3012399 7 More
GO:0046486 glycerolipid metabolic process GO Biological Processes -5.86759713 18 More
GO:0046503 glycerolipid catabolic process GO Biological Processes -7.85666327 9 More
GO:0050727 regulation of inflammatory response GO Biological Processes -68.5964592 121 More
GO:0050729 positive regulation of inflammatory response GO Biological Processes -38.1621935 57 More
GO:0052689 carboxylic ester hydrolase activity GO Molecular Functions -5.71815649 11 More
GO:0052739 phosphatidylserine 1-acylhydrolase activity GO Molecular Functions -3.59511628 3 More
GO:0052740 1-acyl-2-lysophosphatidylserine acylhydrolase activity GO Molecular Functions -3.72958795 3 More
GO:0055088 lipid homeostasis GO Biological Processes -20.8046481 43 More
GO:0055090 acylglycerol homeostasis GO Biological Processes -12.4730141 17 More
GO:0055092 sterol homeostasis GO Biological Processes -21.3864243 34 More
GO:0055094 response to lipoprotein particle GO Biological Processes -14.9317808 12 More
GO:0070328 triglyceride homeostasis GO Biological Processes -12.4730141 17 More
GO:0070542 response to fatty acid GO Biological Processes -13.2686457 21 More
GO:0071396 cellular response to lipid GO Biological Processes -37.0669488 98 More
GO:0071398 cellular response to fatty acid GO Biological Processes -4.09043632 8 More
GO:0071402 cellular response to lipoprotein particle stimulus GO Biological Processes -16.0665913 13 More
GO:0071404 cellular response to low-density lipoprotein particle stimulus GO Biological Processes -11.9646006 9 More
GO:0071496 cellular response to external stimulus GO Biological Processes -17.0078490 52 More
GO:0071813 lipoprotein particle binding GO Molecular Functions -15.1312842 12 More
GO:0071814 protein-lipid complex binding GO Molecular Functions -15.1312842 12 More
GO:0071825 protein-lipid complex subunit organization GO Biological Processes -20.9970896 17 More
GO:0071827 plasma lipoprotein particle organization GO Biological Processes -21.6197515 17 More
GO:0072330 monocarboxylic acid biosynthetic process GO Biological Processes -12.0346130 18 More
GO:0097006 regulation of plasma lipoprotein particle levels GO Biological Processes -27.6960426 22 More
GO:1900076 regulation of cellular response to insulin stimulus GO Biological Processes -8.81141992 11 More
GO:1900077 negative regulation of cellular response to insulin stimulus GO Biological Processes -5.46127869 10 More
GO:1901681 sulfur compound binding GO Molecular Functions -28.2504512 39 More
GO:1903555 regulation of tumor necrosis factor superfamily cytokine production GO Biological Processes -32.3948799 57 More
GO:1903557 positive regulation of tumor necrosis factor superfamily cytokine production GO Biological Processes -20.7768498 23 More
GO:1905952 regulation of lipid localization GO Biological Processes -40.6150331 64 More
GO:1905954 positive regulation of lipid localization GO Biological Processes -22.7388039 24 More
GO:1990777 lipoprotein particle GO Cellular Components -17.5986271 14 More
GO:2000341 regulation of chemokine (C-X-C motif) ligand 2 production GO Biological Processes -5.55591541 5 More
GO:2000343 positive regulation of chemokine (C-X-C motif) ligand 2 production GO Biological Processes -7.34622031 5 More
KEGG pathways: 4 records
KEGG Description Category LogP Number of genes Detail
hsa00561 Glycerolipid metabolism KEGG Pathway -2.22481389 4 More
hsa03320 PPAR signaling pathway KEGG Pathway -10.0668076 12 More
hsa04979 Cholesterol metabolism KEGG Pathway -20.0696655 17 More
hsa05010 Alzheimer disease KEGG Pathway -5.39034067 17 More
Drug-Gene interaction
view
Related drugs: 18 records
Drug name Interaction type Source PMID View
acarbose NCI 8886823 view
adriamycin NCI 10831167 view
asparaginase NCI 9264396 view
clofibrate TTD view
diazoxide NCI 14499880 view
fenofibrate PharmGKB 19207029 view
gemfibrozil TTD view
ibrolipim TTD view
inositol NCI 8063863 view
insulin NCI 152027838727949 view
isotretinoin NCI 2931603 view
labetalol NCI 4050551 view
lovastatin NCI 8663292 view
nadolol NCI 1681747 view
orlistat TdgClinicalTrial view
pravastatin PharmGKB 16103896 view
reserpine NCI 7282227 view
triamcinolone NCI 4077022 view
Related studies: 10 records
Molecular factor Omics type Application Objective MI type Reference
NM_000237.3:c.106G>A genomics myocardial infarction[diagnosis] myocardial infarction Izar MC et al. Atherosclerosis. 2009
NM_000237.3:c.[1421C>G;106G>A;953A>G] genomics acute myocardial infarction[diagnosis] acute myocardial infarction Yang Y et al. J Lipid Res. 2004
NM_000237.3:c.1322+483T>A genomics acute myocardial infarction[diagnosis] acute myocardial infarction Abd El-Aziz TA et al. Mol Cell Biochem. 2011
lipoprotein lipase proteomics old myocardial infarction[diagnosis] old myocardial infarction Johansson J et al. Atherosclerosis. 1991
lipoprotein lipase proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Hitsumoto T et al. J Atheroscler Thromb. 2002
lipoprotein lipase proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Hitsumoto T et al. J Atheroscler Thromb. 2011
NM_000237.3:c.1322+483T>A genomics myocardial infarction[diagnosis] myocardial infarction Shagisultanova EI et al. Mol Gen Mikrobiol Virusol. 2001
NM_000237.3:c.1322+483T>A genomics myocardial infarction[diagnosis] myocardial infarction Tanguturi PR et al. Indian Heart J. 2013
NM_000237.3:c.1421C>G genomics death[prognosis (bad)] ST elevation myocardial infarction Makeeva OA et al. Kardiologiia. 2013
NM_000237.3:c.776-172G>A genomics myocardial infarction[diagnosis] myocardial infarction Matsuoka R et al. Int J Mol Med. 2015
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